Regorafenib

Regorafenib : Uses, Dosage, Side effects, Brands & Price In India - 2026 Guide

What is Regorafenib ?

Regorafenib is a small-molecule tyrosine kinase inhibitor (TKI) that targets multiple proteins involved in cancer-cell growth, tumor blood-vessel formation and tumor progression.

It inhibits several kinase pathways, including VEGFR, KIT, RET, PDGFR, FGFR and RAF-related pathways. By interfering with these signals, regorafenib can help slow cancer-cell growth and the formation of blood vessels that tumors need to grow.

👉Why is Regorafenib Prescribed ?

Regorafenib is used for specific advanced or metastatic cancers.

  • Colorectal Cancer
  • Gastrointestinal Stromal Tumor (GIST)
  • Hepatocellular Carcinoma

How Regorafenib Works

Regorafenib blocks multiple kinase enzymes that cancer cells can use for growth and survival.

It also inhibits pathways involved in angiogenesis, the process through which tumors develop new blood vessels.

By interfering with these pathways, Regorafenib can:

  • Slow cancer-cell growth
  • Inhibit tumor-cell signaling
  • Reduce formation of new tumor blood vessels
  • Slow progression of certain advanced cancers

This is why Regorafenib is classified as a multikinase inhibitor.

How to Take Regorafenib

  • Taken once daily as prescribed.
  • Taken at approximately the same time each day.
  • Taken after a low-fat meal.
  • Swallowed whole with water.
  • Not crushed, chewed or broken.

If a dose is missed, do not take two doses on the same day to compensate.

⚠️ Important Instructions:

  • Take Regorafenib exactly as prescribed by your oncologist.
  • Do not crush, chew, or alter tablets unless your specific product information allows it.
  • Do not stop treatment without consulting your doctor.

Regorafenib Dosage Variants

  • Regorafenib 40 mg

The exact formulation and dosing should follow the prescribed product and your oncologist's instructions.

Side Effects of Regorafenib

Like all cancer medicines, Regorafenib may cause side effects.

Common Side Effects:

  • Fatigue
  • Weakness
  • Diarrhea
  • Nausea
  • Vomiting
  • Decreased appetite
  • Weight loss
  • Hand-foot skin reaction
  • High blood pressure
  • Voice changes
  • Mouth inflammation or stomatitis
  • Rash
  • Fever
  • Pain
  • Infection
  • Increased liver enzymes

👉 Inform your doctor immediately if side effects become severe or persistent.

Precautions Before Starting Regorafenib

Inform your doctor if you have:

  • Liver disease
  • High blood pressure
  • Heart problems
  • A history of bleeding
  • Recent surgery
  • An unhealed wound
  • Planned surgery
  • Any other medical condition

Also inform your doctor about all prescription medicines, OTC medicines, vitamins and herbal supplements, because Regorafenib can interact with other medicines.

Available Brands


Regorafenib Price In India -

The price of Regorafenib in India depends on:

  • Brand
  • Pack Size
  • Manufacturer
  • Generic or innovator product

Patients can also explore:

  • Patient Assistance Programs (PAP)
  • Generic Regorafenib options
  • Affordable oncology medicine suppliers

If You Need More Information about Price You Can Buy From Our Website Supermeds or Contact Us - 8432525386

👉 Many patients search online for the lowest Regorafenib price in India and trusted suppliers offering genuine medicines.

Frequently Asked Questions

What is Regorafenib used for?

Regorafenib is used for certain patients with metastatic colorectal cancer, advanced/metastatic GIST and hepatocellular carcinoma after specified previous treatments.

What is Regorafenib 40 mg?

Regorafenib 40 mg is an oral tablet containing 40 mg of Regorafenib, a multikinase inhibitor used in cancer treatment.

What is the usual dose of Regorafenib?

The standard starting dose is 160 mg once daily for 21 days followed by 7 days off, forming a 28-day treatment cycle.

Can Regorafenib be reduced to 120 mg or 80 mg?

Yes. If significant toxicity occurs, the oncologist may reduce the dose in 40 mg increments. The labeled lowest recommended daily dose is 80 mg.

Should Regorafenib be taken with food?

Yes. It should be taken after a low-fat meal.

Is Regorafenib a chemotherapy medicine?

Regorafenib is more accurately described as an oral targeted anticancer therapy / multikinase inhibitor, rather than conventional cytotoxic chemotherapy.

References

    References

    1. DailyMed – STIVARGA (Regorafenib) Prescribing Information
      DailyMed – STIVARGA Prescribing Information

    2. National Cancer Institute – Regorafenib
      NCI – Regorafenib

    3. NCI Drug Dictionary – Regorafenib
      NCI Drug Dictionary – Regorafenib

    4. MedlinePlus – Regorafenib
      MedlinePlus – Regorafenib

    Medical Disclaimer: This information is for educational purposes only and does not replace advice from a qualified oncologist or other healthcare professional. Regorafenib is a prescription anti-cancer medicine and should be used only under appropriate medical supervision.